Tetrachloroethylene ( perc , tetra , PCE )
نویسنده
چکیده
Current evaluation Conclusion from the previous Monograph: Tetrachloroethylene (Perc) is probably carcinogenic to humans (Group 2A) with the working group finding limited evidence in humans for the carcinogenicity of Perc and sufficient evidence in experimental animals for the carcinogenicity of Perc. In making the overall evaluation, the Working Group considered the following evidence: (i) Although Perc is known to induce peroxisome proliferation in mouse liver, a poor quantitative correlation was seen between peroxisome proliferation and tumor formation in the liver after administration of Perc by inhalation. The spectrum of mutations in proto-oncogenes in liver tumors from mice treated with Perc was different from that in liver tumors from mice treated with trichloroethylene (TCE). (ii) The compound induced leukemia in rats. (iii) Several epidemiological studies showed elevated risks for esophageal and cervical cancer and nonHodgkin lymphoma, which the working group stated was unlikely due to chance although confounding could not be excluded.
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David Ozonoff 4 Too much to swallow : PCE contamination of mains water
PCE (perchlorethylene, also known as 'perc' or tetrachloroethylene), was used in the production of plastic linings for drinking water distribution pipes in the late 1960s and 1970s. This new and relatively untested type of distribution pipe was used in over 700 miles of New England's water distribution systems. Not until 1976 was it discovered that PCE had been leaching into the water from the ...
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